General description
A cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Echalier, A., et al. 2008. J. Med. Chem.51, 737.Bettayeb, K., et al. 2007. Cancer Res.67, 8325.
Packaging
Packaged under inert gas
5 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Regulatory Review (Z)
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