Meriolin 2

Code: 445820-5MG D2-231

General description

A cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B...


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Your Price
€348.40 EACH
Discontinued
€428.53 inc. VAT

General description

A cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Echalier, A., et al. 2008. J. Med. Chem.51, 737.Bettayeb, K., et al. 2007. Cancer Res.67, 8325.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Regulatory Review (Z)

assay≥93% (HPLC)
coloryellow
formsolid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityDMSO: 50 mg/mL
storage conditionprotect from light, OK to freeze
storage temp.2-8°C
Cas Number954143-47-6
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